Former Meath Sports Person of the Year Devin Toner will miss Leinster's crucial Heineken Championships Cup clash with Toulouse at the RDS on Saturday, 1pm.
Toner picked up his injury in the game against Bath at the Aviva at Christmas, and he missed all the Interpros over the festive period.
Leinster will also be without the services of captain Johnny Sexton, Rob Kearney and Robbie Henshaw also miss out.
Scott Fardy's return is a timely boost with Toner missing out and he will partner James Ryan in the second row.
Out-half Sexton last played in the Pro14 defeat to Munster on 29th December and is replaced by Ross Byrne.
Centre Henshaw had returned to training after overcoming a hamstring injury but is not being risked for the game.
Kearney's place at full-back is taken by Jordan Larmour.
Adam Byrne is on the right wing and Dave Kearney on the left.
Rory O’Loughlin and Garry Ringrose form the centre partnership having played together in the Munster game over Christmas.
Luke McGrath starts at scrum-half.
The front row will see Cian Healy, Seán Cronin and Tadhg Furlong scrum down with the back row of captain Rhys Ruddock, Josh van der Flier and Jack Conan at number 8.
On the bench Conor O’Brien is in line to make his European debut having impressed over the last few months in the Guinness Pro14, while Noel Reid is the back-up out-half.
Leinster - Jordan Larmour, Adam Byrne, Garry Ringrose, Rory O'Loughlin, Dave Kearney, Ross Byrne, Luke McGrath; Cian Healy, Sean Cronin, Tadhg Furlong, Scott Fardy, James Ryan, Rhys Ruddock, Josh van der Flier, Jack Conan. Replacements: James Tracy, Ed Byrne, Andrew Porter, Ross Molony, Max Deegan, Jamison Gibson-Park, Noel Reid, Conor O'Brien.
The DART has advised Leinster Rugby that there is a limited service running this weekend due to engineering works taking place in Pearse Station.
All services from the north side will terminate in Connolly Station and all services south side will terminate in Grand Canal Dock Station. Dublin Bus will honour all tickets/Leap Cards.